Mass spectrometry has become a cornerstone of analytical chemistry, allowing scientists to detect, identify, and quantify compounds with remarkable sensitivity. But even the most advanced instrumentation is only as powerful as the data it’s referencing. That’s where Mass Spectral Libraries come in—comprehensive collections of known spectra that act as critical reference points in identifying unknown…
DetailsMetabolomics is a growing scientific discipline dedicated to the detailed exploration of metabolites in living systems. These small molecules, collectively known as the metabolome, play crucial roles in physiological processes and can provide deep insights into the biochemical state of an organism. As this field advances, the accuracy and reliability of metabolomic data analysis become…
DetailsClinical Metabolomics is evolving and revolutionizing how we approach disease diagnostics and treatment personalization. At the heart of this revolution are metabolite-based biomarkers, critical indicators of physiological and pathological states derived from metabolic processes. These biomarkers offer unprecedented insights into the underlying mechanisms of diseases, enabling early diagnosis and the development of targeted therapies. At…
DetailsMetabolomics has matured into a critical facet of systems biology. Presently, it aims at identifying and quantifying the diverse metabolites within a cell, tissue, or organism under various conditions. A key component in metabolomics research is the normalization process, ensuring that data is accurate and comparable across experiments. IROA Technologies offers innovative solutions for metabolomics…
DetailsIn this post I am laying out a framework to think about the space between targeted and untargeted approaches, all of which logically carries the name Semi-targeted. Last week I had a friend tell me he was doing a “semi-targeted” analysis by retrieving only peaks that he knew he could name. He still couldn’t quantitate them…
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