Fatty Acid Metabolite Library of Standards (FAMLS) is a collection of 96 high quality small biochemical molecules in an economical, ready-to-use format. This library of standards is most commonly used for metabolite qualification and quantification for MS.

Cat No. FAMLS: $1,610.00

FAMLS Kit Contents: Plate Map, User Manual, MLSDiscovery software tool

Preparation Instructions The Compounds in this metabolite library can either be used as standards and injected individually or a strategy may be employed to pool compounds to allow multiple mixture to be analyzed per injection. For more information, please refer to the Product Sheet.

Storage/Stability Recommended storage once solubilized at –20 °C, long-term at –80 °C; protected from moisture and light.  Avoid repeated freeze/thaw cycles.

Precautions and Disclaimer The FAMLS is for laboratory research use only. Wear safety glass and handle with gloves. Avoid contact with skin and eyes.

Legal Information FAMLS is a trademark of IROA Technologies LLC.

What is meant by fatty acids, their functions, and related diseases?

The human body carries out numerous biochemical processes that help it work and function well throughout the day, such as breaking down food to simpler compounds so that the body can utilize them to generate energy and supply oxygen for various processes that operate on their own within microscopic cells and their membranes. One important macronutrient component in the body is the family of molecules called fatty acids. Fatty acid metabolites participate in various metabolic processes.

There are two basic different types of processes, namely catabolic and anabolic processes.

In the catabolic process, the fatty acid metabolites are oxidized through beta oxygen oxidation and the citric acid cycle. And through this process, energy is produced that takes the form of ATP.  In the anabolic process, fatty acids act as vital precursors to ketone bodies, triglycerides, and other hormones and messengers. In another type of anabolism, fatty acids form other compounds such as second messenger and local hormones. But the basic role of anabolism is that it allows fatty acids to construct the cell membrane. As you read along, you will encounter the different functions of fatty acids alongside some related disorders.

Functions of fatty acids in the body

Fatty acids constitute a major proportion of the plasma membrane of all cell types in the human body. The major product of the fatty acid metabolites process are prostaglandins. Just this product alone is known to have different effects in different animals as they are present in all tissues in both humans and animals. They are also known to aggregate the platelets in the blood.

Another major function of prostaglandins is a physiological one. They contribute to preventing unnecessary clot formation. They also maintain and regulate smooth muscle tissue contractions. Now that we know some of the functions of fatty acid metabolites let’s move further with related pathological implications and disorders.

Some major pathological complications

Fatty acid metabolic disorders are also known as fatty acid oxidation disorders. The common issue of these disorders is the inability to generate energy within different parts of the body, such as muscles. While some fatty acids promote good health, others deteriorate it.

  • Sometimes the inflammatory process meant to protect the body turns into severe inflammation, which causes diseases like cancers, arthritis, etc. Fatty acids like Omega 3 act as a vital preventive component for cardiovascular diseases or CVD.
  • The brain is a lipid-based organ and contains different fatty acids, from Omega 3 to Omega 6. Due to decreased Omega 3 fatty acids, aged people have Alzheimer’s and other neuropsychiatric diseases. Low levels of fatty acids also hinder brain functioning in both adults and infants.
  • Arthritis refers to the inflammation in the joints. Metabolic changes in the fatty acids, especially stearic acid levels, were found in increased proportions in such patients. But some fatty acids like Omega 3 reduce the severity of this condition to a certain extent.

I hope you enjoyed this brief summary of some of the fatty acid metabolites and fatty acid metabolite processes, their different functions, and disorders. A fact is to be noted that despite the advancements in medicine, there are still many paths that remain undiscovered. With more advanced research and persistent hard work from healthcare professionals, things will get better. Emerging fields like metabolomics will have a huge impact in the discovery and diagnosis of fatty acid metabolite-related diseases.