1. IROA-LTRS
Long-Term Reference Standard
- Paired 1:1 mixture of labeled U-5% and U-13C metabolites
- Analyzed every 10 samples for QC
- Builds triply redundant dictionary
TruQuant Yeast Extract Semi-targeted QC Workflow Kit
Made from unique fully-labeled S. cerevisiae yeast extract containing 100s of polar primary metabolites and spanning a broad range of metabolic classes.
- Semi-targeted, LC-MS-based analysis workflow
- 600 -1000 labeled metabolite standards
- Suppression-corrected measurements
- Batch-to-batch error correction
- Dual MSTUS sample normalization
- Verified metabolite ID and quantitation
- Compatible with major LC-MS platforms
- ClusterFinder automated process
500+
Polar Metabolites
Unique metabolites derived from yeast extract
90
Samples Per Kit
Economical solution for high-throughput labs
$200
Per 90 Samples
Cost-effective metabolomics QC workflow
3-Step
Workflow
Simple, robust and reproducible process
Vendor
Agnostic
Compatible with major LC-MS platforms
Why TruQuant?
Traditional metabolomics workflows suffer from significant losses of signal due to matrix effects, co-eluting interferences, retention time drift, as well as poor sample normalization.
TruQuant introduces a dual-standard approach using:
IROA-LTRS (Long-Term Reference Standard)
For system QC and dictionary generation
IROA-IS (Internal Standard)
For accurate quantitation and normalization
Together, they deliver accurate, reproducible, and comparable metabolomics data across experiments, instruments, and laboratories.
How the TruQuant Workflow Works
1
Analyze Samples
Run experimental samples with IROA-IS. Inject IROA-LTRS every 10 samples as QC Standard to account for fluctuations in mass and retention time drift.
2
Build Metabolite Dictionary
ClusterFinder software generates a "dictionary" of RT, m/z, formula and physical characteristics from the analysis of IROA-LTRS.
3
Identify & Quantitate
Dictionary and IROA-IS enable compound identification, suppression correction, normalization, and improved metabolomics data accuracy.
What's Included
2. IROA-IS
Internal Standard
- Labeled 95% U-13C metabolites
- Spike into samples for quantitation
- Yardstick for accurate measurements
3. ClusterFinder Software
Powerful Analysis Engine
- Generates LTRS libraries
- Identifies and quantifies compounds
- Corrects ion suppression and other ion losses
- Normalizes data
- Provides daily instrument QQC
- Requires minimal human oversight
4. TruQuant User Manual
Comprehensive Guide
- Step-by-step instructions
- Workflow setup and best practices
- Troubleshooting and FAQs
Summary of Benefits
Daily instrument QA/QC
Economical $200 for 90 samples
No false data; removal of artifactual peaks
Accurate compound formula ID for MS alone
Corrects for ionization losses for better quantitation
Normalizes samples to a universal standard
Yeast metabolites characterized by multiple LC-MS methods
ClusterFinder builds libraries, IDs and quantitates
Mass-spec vendor agnostic support
Supports biomarker discovery
PERFORMANCE
Proven Across Platforms and Matrices
The TruQuant Workflow Kit delivers highly reproducible quantitative metabolomics across diverse analytical platforms and biological sample types, enabling consistent normalization and confident metabolite measurement.
- 1% median CV achieved across platforms
- 11% → >90% ion suppression accurately corrected
- Validated using multiple biological matrices and cell models
- Compatible with LC-MS, HILIC, RPLC, and IC-MS workflows
- Thousands of metabolites normalized with high precision
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Powered by BiozHelpful Resources
Routinely Identified Compounds in Internal Standard
DownloadReproducibility of Metabolomic Profiles (Round Robin Study)
DownloadIon suppression correction and normalization for non-targeted metabolomics
DownloadBatch-to-batch error correction
DownloadHow to Set Up and Run a C13-labelled Yeast Extract Calibration
DownloadReady to Improve Quantitative Accuracy?
TruQuant delivers reliable identification, ion suppression correction and normalization to elevate your metabolomics research.